Explanation should include

appropriate use of different opioids in various practice settings
the interactions, risks, and intolerance of prescription opioids
the role and effectiveness of opioids in acute, sub-acute, and chronic pain
a reassessment of opioid use based on stage of pain
contemporary treatment guidelines, best practices, health policies, and government regulations related to opioid use
use of opioids in pain management of patients with substance abuse disorders, in recovery, and in palliative/end-of-life care.

Process/Skill Questions:

When should risk factors regarding opioids be reviewed with the patient?
What are the options when treating patients with a history of substance abuse?
What government regulations and policies are in place to improve the safe administration of opioids?